Letrozole Groundwork and History

Letrozole first outburst onto the market place in 1997 when it was granted approval from the FDA and marketed past Novartis under the name of Femara.

Despite this, the drug is more commonly referred to past its generic name of letrozole.

But is letrozole a steroid? The curt respond is no, but it is usually associated with anabolic steroid utilise.

This chemical compound belongs to a type of drugs known as aromatase inhibitors, all of which accept the ability to dramatically reduce the effects that estrogen has on the body. Letrozole was originally developed to treat breast cancer in post-menopausal women merely the bodybuilding community quickly identified off-label uses too.

Due to its powerful anti-estrogenic consequence, letrozole became sought after by bodybuilders who were taking anabolic steroids. This is considering although bodybuilders seek to increase their testosterone levels with anabolic steroids, this causes an interaction with the aromatase enzyme which in turn pushes up the levels of estrogen in the body.

Every bit an AI, letrozole works in a very unlike style to Nolvadex, some other type of anti-estrogenic drug known as a SERM. Nolvadex merely blocks the estrogen receptor without affecting the levels circulating in the body. Letrozole has a far more than powerful action, not simply actively lowering the amount of estrogen circulating past inhibiting its release merely simultaneously increasing the production of testosterone too.

For any anabolic steroid user who is experiencing estrogenic side furnishings, this lowering of estrogen levels can be very useful.

Stacking info

Letrozole isn't a drug which is by and large used on its own because its ability to increase testosterone product is small.

Instead, a letrozole stack typically includes at least one – if not more than – anabolic steroids which could accept an estrogenic result. Not all anabolic steroids produce the same results and some interact directly with the aromatase enzyme. In these circumstances, letrozole tin exist very useful to accept as a precautionary measure to stop unwanted effects developing.

picture of letrozole chemical structure

Letrozole can too be added during a wheel if there are any estrogenic effects which have adult, such as water retention or gyno.

How it is administered

You will exist able to detect Letrozole pills but these are usually only obtained with a prescription. If you lot purchase letrozole online, y'all may be able to find tablets from culling sources.

Yet, it's much more mutual to purchase Letrozole as a liquid. This is sold as a research chemic and so is far more widely available.

Dosage info

The Letrozole dosage depends on whether you're planning on using the drug as a preventative measure out or because yous've noticed the start of estrogenic side effects.

If y'all're purely being cautious, then information technology's normally possible to take a much more bourgeois dose of the drug. If, even so you lot've noticed the early on signs of gyno, then you'll need to be much more aggressive with your dosage.

The typical dosage range starts at 0.25mg and increases up to 1mg, taken every other day.

The tablets normally come in a standard dose of 2.5mg but this will almost certainly be likewise strong for regular use. The only potential exception is for treating gynecomastia where 7-14 days at two.5mg may just blast abroad whatever early signs.

Half life info

The half life of Letrozole is two days which means that it won't disappear from the system quickly and y'all'll only have to dose every other mean solar day to maintain peak serum levels.

Positive effects

For bodybuilders, letrozole will assistance to strip out the unwanted estrogenic furnishings and provide a much bacteria and more ripped appearance. Estrogen can sometimes crusade water retentivity and a much softer, puffier appearance. Letrozole tin can go rid of any excess water, creating a much leaner, hardcore wait to the muscles.

In some cases, the water retentivity can be so problematic that it tin can increase the overall blood force per unit area. This could lead to other cardiovascular problems developing if non brought back under command.

Gynecomastia is possibly one of the primary concerns for bodybuilders taking anabolic steroids and can ruin a lean, hard advent. Once established surgery can be the only solution to reverse the effects. Gyno is caused by an excess of estrogen merely letrozole is and then powerful information technology can completely blackball gyno, fifty-fifty afterwards it has started to develop.

Potential side furnishings

Letrozole is a very powerful drug and although it tin can exist invaluable in reducing the androgenic furnishings of anabolic steroids, it can carry some unpleasant side effects of its own.

In general, Letrozole side effects can include weakness and fatigue but if the individual is taking anabolic steroids, this is unlikely to be the case. The only time information technology'southward likely to become a problem for bodybuilders is during a pre-competition harsh cutting cycle, where training is intense and calorific intake is low.

The other symptoms yous might experience include hot flashes, headaches, pain in the joints, raised blood pressure level and depression.

Os mineral density can likewise be reduced by Letrozole only one time again, this consequence should be counteracted past the increase in bone density which is often the result of anabolic steroid use.

One side event of Letrozole that remains a concern however is the potential effect on cholesterol. Studies have shown that HDL tin exist reduced by Letrozole specially when combined with an anabolic steroid, with the effect not being only additive but accumulative. When these two types of drugs are taken together HDL cholesterol tin can drop past as much as 20%.

Therefore, a good for you lifestyle is essential, with particular attention to eating a clean diet and including cardiovascular do in your training authorities. Some individuals observe adding an antioxidant into a Letrozole stack is helpful.

Estrogen can play a function in keeping the skin and hair healthy only although the drug will decrease estrogen levels, letrozole and hair loss are not normally connected.

Contraindications

This drug is currently banned in India because i study showed a link to nativity defects in babies. Withal, a Canadian study was unable to replicate the results and in the rest of the world, Letrozole remains licensed for use.

Because of the known effect on cholesterol, anyone with a history of raised cholesterol or cardiovascular disease should avert Letrozole. A SERM could be substituted in its place; it'due south not quite as effective in managing estrogenic effects but in many cases it is sufficient.

Is information technology safe for women to employ?

Although some female bodybuilders may want to reduce their overall fat levels, tinkering with estrogen is much more of a problem.

Estrogen is essential to the female body and many of its functions and an AI tin can drop levels too low, particularly one and so powerful as Letrozole.

For this reason, Letrozole is not recommended for whatsoever women of child-bearing age, and only to be used cautiously in others.  This is considering there is an interaction between letrozole and fertility.

Volition Percentage be required?

Letrozole helps to promote natural product of testosterone so when taken on its ain, there's no negative effect on the body'southward own testosterone. The trouble arises because Letrozole is typically taken alongside another drug which volition suppress the production of testosterone.

Therefore, while PCT isn't necessarily to counteract the effects of Letrozole by itself, Per centum will be required in order to back up the return to natural production of testosterone because of the effects of the other drugs taken.

Letrozole can help to stimulate the body to produce testosterone but it'due south not sufficient to accept in isolation every bit PCT; this is because of the suppressing action on the estrogen levels in the trunk. PCT is supposed to bring the torso dorsum to natural levels of hormones so suppressing estrogen will impair this end goal.

Typical cost

The one official brand of Letrozole is Femara which is sold in blister strips, each containing ten 2.5mg tablets. It is possible to buy generic brand Letrozole and compared with other drugs, there's a much lower incidence of counterfeits and fakes.

There are two dissimilar grades of letrozole for sale available: pharmaceutical and research.

Femara is a pharmaceutical grade product; some of the generic brands may also be pharmaceutical form only that tin can exist said with far less certainty. To buy letrozole at a pharmaceutical grade, you can expect to pay $eight-10 per 2.5mg tablet. If yous buy from a supplier who specifies a minimum quantity for each order, you tin can purchase letrozole from $2-four per tablet. Minimum limits are often set at a price of between $200-400.

Research grade letrozole typically comes in liquid form where a 30ml bottle contains 2.5mg per ml. This can then be administered either via a dropper, a syringe or a measured spray pump. You can expect to pay approximately $50 per canteen.

Legality of purchase and its usage in the U.s.

In the United states of america, although the FDA has granted approval for use in humans Letrozole remains a prescription drug. This ways that a doctor may only prescribe information technology if there is a legitimate medical cause. It may non be prescribed for recreational purposes such as bodybuilding.

Therefore, to larn Letrozole in the US to use alongside anabolic steroids means resorting to illegal ways. However, because information technology's not classified every bit a controlled substance, there's no harsh penalties for either use or distribution, despite the fact it cannot be readily purchased over the counter.

There is however 1 loophole in the law to be aware of: the ability to purchase it as a research chemical. This makes it much easier to source and purchase in liquid form.